Animal trypanosomosis (AT) is caused by parasites transmitted by tsetse and other blood-sucking flies. The disease is a scourge for livestock keepers in Africa , affects humans and could spread to Europe . COMBAT aims to reduce the AT burden in Africa using the concept of progressive control pathway (PCP) . The PCP is an innovative, risk-based approach to disease reduction or elimination through successive, achievable steps. A consortium of excellence, with European and African research institutes, national veterinary authorities from across Africa, and leading international organizations guarantees successful project implementation and maximal impact on the SDGs. COMBAT will 1) improve basic knowledge on AT; 2) develop innovative control tools; 3) improve surveillance and control strategies; and 4) build capacity and raise awareness. Knowledge gaps on epidemiology, chemical ecology, vector competence, and immune and metabolic aspects of tolerant livestock will be filled. Innovative tools include environmentally friendly vector control technologies and electronic antigen capture tests. Surveillance will be enhanced by establishing information systems, strengthening reporting, and modelling risk in Africa and Europe. The socio-economic burden of AT will be assessed. Guidelines for national control strategies will be developed and implemented. COMBAT will draw on the extensive partners’ experience in other EU projects and strengthen existing partnerships in the field of AT control.